Frenkie de Jong
De Jong has not played for Barcelona in almost a month due to an ankle injury but will be given time to prove his fitness, while Saudi Arabia-based Wijnaldum, 33, made a return to the national team in March following a nine-month absence.
Barcelona President Joan Laporta backed Koeman last week but said the board would not shirk tough decisions if they needed to be made.
The Dutch team hopes to shock Real Madrid in front of their fans when they meet on Tuesday night at the UEFA Champions League round of 16 second leg.