Schwartzman
Murray, currently ranked 172nd, lost 6-4 7-6(6) to Argentine second seed Diego Schwartzman as the Briton failed to match his 2019 display when he triumphed in Antwerp
The 25-year-old Argentine, who reached the French Open quarter-finals last month, saved four break points in the final game.
Top seed Rafa Nadal was rattled by a feisty challenge from Diego Schwartzman but held firm to fend off the diminutive Argentine.