Karolina Pliskova
Raonic suffered a thigh injury in March and returned to the tour after a three-month gap.
“I knew I have to serve good today,” said Rybakina, who hit 11 aces against Pliskova.
Sharapova was back on Roland Garros' main stage for the first time in three years.
Top seed Simona Halep recovered from a slow start before racing away to a 6-3 6-2 victory over big-serving Czech sixth seed Karolina Pliskova in their Australian Open quarter-final on Wednesday.
Karolina Pliskova's eight-week run as world number one ended Wednesday with a US Open quarter-final loss.
World number one Karolina Pliskova needed just 46 minutes to defeat American Jennifer Brady 6-1 6-0 at Arthur Ashe Stadium
Here are five things to watch out for on day six of the U.S. Open on Saturday.
Karolina Pliskova survived a scare to advance to the third round of the U.S Open with a 2-6 6-3 6-4 comeback win against Nicole Gibbs on Thursday.