CONCACAF
Philadelphia, who made the MLS Cup final last year and have a dominant record at home, were poised to be Miami's biggest test since the latter added the Argentinean striker to their roster last month.
The top three in the eight-team group qualify automatically for Qatar 2022 with the fourth-placed finisher going into an intercontinental playoff.
The draw for the tournament takes place on April 10 and it kicks off on June 15 in Pasadena.
CONCACAF's governing council has agreed to launch a new Nations League tournament, for teams in North and Central America and the Caribbean.