The Red Devils will go to Niger without several key players like Mohamed El Shenawy, Hussein El Shahat, Salah Mohsen and Mohamed Magdy Afsha.
Zamalek are back to the driving wheel as they are leading the standings by two points, with five games remaining in the league campaign, including tonight’s matches
The Red Devils are six points behind the leaders Zamalek with two games in hand and they hope to close the gap at the top with a victory tonight.
Pitso Mosimane and his men hope to add another three points to their tally of 51 points and close the gap with league leaders Zamalek at the top.
Al Ahly extended their record as the club with most CAF Champions League titles to a total of 10 and they are five titles ahead of Zamalek and TP Mazembe.
Castro wants to make history with his team and achieve the CAF Champions League title on Saturday when they face Al Ahly.
Mosimane hopes to guide his team to the title again and he believes that his players are ready to clinch the title.
Al Ahly participated in the CAF Champions League final on a record 13 previous occasions, having secured the title on nine occasions and they are chasing the 10th title in the club's history.
Mosimane decided to rest the team's starting midfielder after having a fantastic run with the team in the last couple of matches.
Al Ahly were held to a 2-2 draw against Pyramids at home on Thursday night, losing two important points in the race to the title.
The two teams are heading into the game with different emotions.
Mosimane understandably sticks to the starting XI which performed so impressively in the team's 1-0 win in the first leg in Tunisia, only changing Salah Mohsen by Mohamed Magdy Afsha
Mosimane knows that Esperance of Tunisia have nothing to lose when they face Al Ahly in the CAF Champions League semis second leg on Saturday night.
It is expected to be a crunch 90 minutes to decide who will secure the ticket to the CAF Champions League final.
Mohamed Hany is ruled out of the game despite his return to the training sessions this week.
Al Ahly secured their victory with two second-half goals by Mohamed Sherif and Salah Mohsen after the first half ended in a goalless draw.
Mosimane will use his typical 4-4-2 formation after changing the formation to 5-3-2 in the last game against Mamelodi Sundowns in South Africa.
Mngqithi believes that his team has everything needed to overturn their loss against Al Ahly in the first leg of the CAF Champions League quarter-finals.
The two teams will face off on Saturday night at Al Ahly stadium in El Salam City in the first leg of the quarter-finals.
Al Ahly's head coach Pitso Mosimane spoke after the game and hailed the performance of his players in the game after losing five points in the last two games.