The first derby in Ramadan goes back to 7 April 1957 and ended with a 2-0 win for the Red Devils thanks to a brace from the club's legend El-Dhizhui.
Al Ahly will count on their back-up goalkeeper Ali Lotfy, who will appear in the derby for the first time in his career.
Zamalek enter the game in high spirits as they are on an impressive run under the leadership of Patrice Carteron.
If the game finished in a draw, the two teams will face off again in a match to decide the league champion.
Al Ahly and Zamalek booked their places in the Egyptian Cup round of 16 after a strong start to the competition.
It became clear that Junior Ajayi will be out of the game as he suffered an injury in his hamstring muscle during the game against Simba SC
Al Ahly will face the Tanzanian champions on Friday night in the last game of the CAF Champions League group stage.
The Red Devils were behind by two goals at the break but two goals from Al Ahly defenders Badr Benoun and Yasser Ibrahim secured a point for Al Ahly.
Al Ahly will attack Al Merrikh SC in Sudan with four players as Al Ahly’s head coach Pitso Mosimane will count on Sherif, Marwan, Ajayi, and Afsha.
Al Ahly will face the Sudanese giants at Al Hilal stadium in Matchday 5 of the CAF Champions League group stage.
Zamalek will have a win-or-die game against the Algerian giants MC Alger when the two teams face off on Saturday.
This injury forced Soliman to miss many important games for Al Ahly this season, including the FIFA Club World Cup in Qatar.
Zamalek’s spokesperson, Amr El Dardir, denied on Saturday the reports that linked the club with a move for Al Ahly’s former Moroccan striker, Walid Azzaro.
Despite missing their outstanding spiker, Ahmed Salah, the Red Devils dominated the game from the start and won the match in three straight sets.
Fathy suffered a fracture in the radius muscle and he will be ruled out for the next two months.
Zamalek are leading the league table with 29 points, four points ahead of Al Ahly, who still have a game to play against Tersana.
Sherif believes that the victory will have a great impact on the Red Devils in their journey to defend their CAF Champions League title.
Al Ahly women's handball team defeated arch-rivals Zamalek 27-20 on Wednesday night to snatch the Egyptian Cup title.
Crateron said that he trusts the players’ abilities to overcome the difficult circumstances and secure qualification to the next round.
The Red Devils defender has been sidelined since the game against Bayern Munich in the FIFA Club World Cup due to a hamstring injury.